Sabin Monovalent Oral Polio Vaccines: Review of Past Experiences and Their Potential Use after Polio Eradication

Paralytic poliomyelitis associated with Sabin monovalent and bivalent oral polio vaccines in Hungary.

Historical records of patients with vaccine-associated paralytic poliomyelitis (VAPP) in Hungary during 1961-1981 were reviewed to assess the risk of VAPP after oral polio vaccine (OPV) administration. A confirmed VAPP case was defined as a diagnosis of paralytic poliomyelitis and residual paralysis at 60 days in a patient with an epidemiologic link to the vaccine. Archived poliovirus isolates ...

Monovalent oral polio vaccine: Gates Foundation funds new polio vaccine to accelerate eradication efforts.

Polio eradication, and after...

Assessing the stability of polio eradication after the withdrawal of oral polio vaccine

A fundamental complexity of polio eradication is that the elimination of wild poliovirus (WPV) alters the risk-benefit profile of using oral polio vaccine (OPV)—as WPV is eliminated, OPV produces an increasing proportion of the paralytic disease burden since, in rare instances, OPV causes paralysis in vaccine recipients and generates circulating vaccine-derived polio outbreaks (cVDPV) in under-...

Polio eradication.

The goal of polio eradication in the Western Pacific Region is within reach. The last case of polio seen in the region occurred in Cambodia in March 1997 and the region aims to be certified polio-free by the World Health Organization (WHO) in the year 2000. The Global Commission for Certification of Eradication of Poliomyelitis has specified three criteria to be fulfilled by countries in order ...